Multiple renal and liver cysts in a Siberian hybrid tiger

Polycystic kidney disease (PKD) is an inherited commonly reported in cats, but rarely big cats. It associated with formation of cysts the kidneys. This article describes clinical, pathology and immunohistochemistry findings PKD a Siberian hybrid tiger. A 16-year-old female captive tiger showed inappetence, weight loss, polyuria, polydipsia. Within six months, its body hydration status were progressively declining. Although hematology parameters normal, serum creatinine urea levels elevated. Ultrasonography kidneys presence cysts. The animal was euthanized necropsied, revealing multiple both liver. These samples subjected to histopathology using routine stain, special histochemistry, immunohistochemistry. lined by various types epithelial cells. Most renal tubular epithelium severe vacuolar degeneration, accompanied bacterial colonies pelvis. Masson’s trichrome stain demonstrated mesenchymal stroma at periphery Immunohistochemistry different staining intensity β-catenin, E-cadherin, vimentin parts tubules, suggesting involvement epithelial-mesenchymal transformation. diagnosed based on clinical pathological examination. first report tiger, potentially useful for future study wildlife medicine conservation.